GLP-1 Comparison Guide
Choose the right GLP-1 medication for you
Compare FDA-approved options like Wegovy and Zepbound side by side — then connect with a licensed clinician to find the plan that fits your goals.
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A detailed comparison of GLP-1 medications
GLP-1 medications have transformed chronic weight management, but not every option works the same way. Wegovy (semaglutide) and Zepbound (tirzepatide) are both FDA-approved — yet they differ in mechanism, dosing, and clinical outcomes.
Choosing the right medication depends on your health history, tolerance, and goals. A licensed Ongo clinician helps you weigh the evidence — never a one-size-fits-all questionnaire.
- Active ingredient and mechanism of action
- Dosing frequency and titration schedule
- Average clinical trial weight-loss results
- Common and serious side effects
- Eligibility and contraindications
Side by side
Wegovy vs. Zepbound: a side-by-side comparison
Key differences at a glance. Always consult a licensed clinician before starting any prescription medication.
| Feature | Wegovy (Semaglutide) | Zepbound (Tirzepatide) |
|---|---|---|
| FDA Approval | Approved for chronic weight management | Approved for chronic weight management |
| Active Ingredient | Semaglutide (GLP-1) | Tirzepatide (GLP-1/GIP) |
| Administration | Subcutaneous injection | Subcutaneous injection |
| Dosing Frequency | Once weekly | Once weekly |
| Avg. Weight Loss | ≈ 15% at 68 weeks* | ≈ 22.5% at 72 weeks* |
| Max Maintenance Dose | 2.4 mg weekly | 15 mg weekly |
| Common Side Effects | Nausea, diarrhea, constipation, vomiting | Nausea, diarrhea, vomiting, constipation |
*Based on published clinical trial data. Individual results vary. Prescription required. This comparison is for educational purposes and does not constitute medical advice.
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−29 lbsAvg. loss in 6 months
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BeforeAfterYour weight 35 lbs
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The science
How GLP-1 medications work
Slows down digestion
GLP-1 medications delay gastric emptying so you feel fuller longer after smaller meals.
Reduces appetite
Signals to the brain help quiet hunger cues and reduce cravings between meals.
Regulates blood sugar
Improved insulin response supports metabolic health alongside gradual weight loss.
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Appetite signals
GLP-1
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Slower digestion
Safety first
Common and potential side effects
Common side effects
- Nausea
- Diarrhea
- Constipation
- Vomiting
- Injection-site reactions
- Fatigue
Serious side effects
- Pancreatitis
- Gallbladder disease
- Kidney problems
- Severe allergic reactions
- Thyroid C-cell tumors (in rodents)
- Suicidal thoughts or behavior
Black box warning
GLP-1 medications may cause thyroid C-cell tumors in rodents. It is unknown whether this occurs in humans. Do not use if you or a family member have had medullary thyroid carcinoma or MEN 2. Report any neck lumps, hoarseness, or difficulty swallowing to your clinician immediately.
Transparent pricing
Estimate your savings with Ongo Care
Estimate your savings
Adjust your weights to see a rough monthly cost comparison. Final pricing depends on your clinician's recommendation.
Estimated program length5 months
Traditional clinic cost$2,250
Ongo Care estimate$995
Potential savings: $1,255
Compare costs across providers
Estimated monthly medication + care costs. Actual pricing varies by plan and medication.
Traditional clinic$450/mo
Retail pharmacy$380/mo
Ongo Care$199/mo
Your journey
How to get started with Ongo Care
01 Complete your free assessment
Share your health history, goals, and BMI through our secure intake — takes about 5 minutes.
02 Consult with a licensed provider
A board-certified clinician reviews your case via telehealth and recommends the right GLP-1 option.
03 Receive your personalized plan
If prescribed, your clinician creates a titration schedule tailored to your tolerance and progress.
04 Medication delivered to your door
Your prescription ships discreetly from a licensed U.S. pharmacy with cold-chain handling when needed.
05 Ongoing support
Your Care Team checks in, adjusts dosing, and is available 24/7 through secure messaging.
The Ongo difference
Why choose Ongo Care for weight loss?
Personalized plans
Every plan is built around your health history, goals, and clinician recommendations.
Expert medical team
Board-certified physicians review every case before any prescription is considered.
Affordable pricing
Transparent monthly pricing with no hidden visit fees or surprise add-ons.
Secure and private
HIPAA-compliant telehealth with discreet pharmacy delivery to your door.
Same-day visits
Connect with a licensed clinician quickly — no waiting rooms required.
Fast delivery
Medication ships from a licensed U.S. pharmacy, typically within 3–5 business days.
Ongoing coaching
Care Team support from evaluation through delivery and beyond.
FDA-approved options
Wegovy, Zepbound, and other GLP-1 medications when clinically appropriate.
Ready to start your weight loss journey?
Take a free evaluation today. A licensed clinician will review your history and help you choose the right GLP-1 plan.
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