Zepbound® · Tirzepatide
Your solution for weight loss
A once-weekly dual GIP/GLP-1 injection FDA-approved for chronic weight management — prescribed and monitored by licensed clinicians through Ongo.
HIPAA CompliantLicensed PhysiciansFDA-Approved RxTelehealth Care
The Ongo difference
Physician-guided care, built around you
Weight loss support
GLP-1 therapy that works with your natural appetite signals for gradual, sustainable progress.
Medical guidance
Every patient is evaluated by a licensed clinician before any prescription is considered.
Personalized plans
Dosing schedules tailored to your tolerance, goals, and clinician recommendations.
Ongoing coaching
Care Team support from evaluation through delivery and beyond.
About Zepbound
What is Zepbound?
Zepbound is a prescription tirzepatide medication FDA-approved for chronic weight management in adults with obesity or overweight with a weight-related condition. It activates GLP-1 and GIP receptors to help regulate appetite alongside lifestyle changes.
See if you qualify →How it works
How does Zepbound work?
Zepbound's dual-action mechanism slows digestion, improves insulin sensitivity, and reduces hunger signals — helping you feel satisfied with less food under clinician supervision.
Get Started Now →Your journey
Our step-by-step process
Complete your free online evaluation
Share your health history, goals, and BMI through our secure intake — takes about 5 minutes.
Meet with a licensed clinician
A board-certified provider reviews your case via telehealth and determines if Zepbound is appropriate.
Receive your personalized plan
If prescribed, your clinician creates a titration schedule tailored to your tolerance and progress.
Medication delivered to your door
Your prescription ships discreetly from a licensed U.S. pharmacy with ongoing Care Team support.
Is Zepbound right for you?
- Adults with obesity (BMI ≥ 30)
- Adults overweight (BMI ≥ 27) with a weight-related condition
- Committed to nutrition and activity changes alongside medication
- No contraindications identified by your clinician
Safety
Important safety information
Common side effects
Nausea, diarrhea, vomiting, constipation, and injection-site reactions — most common during dose increases.
Serious risks
Thyroid tumor risk in rodents. Not for people with medullary thyroid carcinoma history or MEN 2.
Do not use if
Pregnant, breastfeeding, or allergic to tirzepatide or any Zepbound ingredient.
Talk to your doctor
Share your full medical history. Your Ongo clinician reviews risks before prescribing.
Clinical trial results
| Measure | Zepbound | Placebo |
|---|---|---|
| Avg. weight change (72 weeks) | −22.5% | −2.0% |
| Patients losing ≥5% body weight | 89% | — |
| Patients losing ≥15% body weight | 55% | — |
*Based on SURMOUNT-1 trial data. Individual results vary. Prescription required.
Watch our Zepbound overview
How to inject Zepbound
- Wash hands and choose your injection site.
- Attach a new needle and check the pen flow if needed.
- Pinch skin, insert needle, and press until dose is delivered.
- Dispose of the needle safely and store the pen refrigerated.
Rotate sites weekly. Your clinician guides your first injection.
AbdomenFront of thighUpper arm
Dosage & administration
Zepbound is titrated gradually. Your Ongo clinician personalizes the schedule.
- Weeks 1–4: 2.5 mg once weekly
- Weeks 5–8: 5 mg once weekly
- Weeks 9–12: 7.5 mg once weekly
- Further increases to 10 mg, 12.5 mg, or 15 mg per clinician guidance
Social proof
Patient testimonials
Real stories from patients on physician-guided Zepbound care.
The appetite changes were noticeable within the first few weeks. Having a real doctor guide the dosing made me feel safe the whole way.
Sarah M.
Ongo patient · on Zepbound
I appreciated that nobody rushed me. The evaluation was thorough, and my care team answered every question before I started.
James T.
4,000+Patients trust Ongo
Meet our medical team
Dr. Miller
Licensed Physician
Physician-guided weight loss and metabolic health consultations.
Dr. Niles
Board-Certified Physician
30+ years of clinical experience in patient-centered obesity care.
Dr. Krasne
Licensed Physician
Board-certified clinician focused on individualized treatment planning.
Dr. Bugailiskis
Board-Certified Physician
Evaluates patients based on health history, goals, and clinical needs.
Zepbound is FDA-approved for chronic weight management in adults with obesity (BMI ≥ 30) or overweight (BMI ≥ 27) with a weight-related condition.
Both contain tirzepatide. Zepbound is FDA-approved for weight management; Mounjaro is approved for type 2 diabetes. Dosing may differ by indication.
Yes — if clinically appropriate after a licensed clinician evaluation.
Ready to see if Zepbound is right for you?
Take a free evaluation. A licensed clinician will review your history and recommend a plan.
Get Started →Zepbound® is a registered trademark of Eli Lilly and Company. Educational content only — not medical advice.